Jonathan Henninger

Jonathan Henninger is an Assistant Professor in the Department of Biological Sciences at Carnegie Mellon University (CMU), part of the Mellon College of Science. His research focuses on RNA's role in regulating gene expression and cell fate through molecular biology, soft-matter physics, and super-resolution imaging approaches. The Henninger Lab investigates RNA's interactions with proteins and condensates to uncover mechanisms underlying gene control and disease.

Education: Ph.D. in Developmental and Regenerative Biology from Harvard University, followed by postdoctoral training at the Whitehead Institute for Biomedical Research, MIT.

Key research interests include RNA-mediated transcriptional regulation, nuclear condensates, RNA structure-function relationships, and the development of RNA-based therapies. The lab combines experimental and computational methods to study how RNA defects contribute to human diseases like cancer and neurodevelopmental disorders.

Recent work includes identifying how RNA synthesis patterns nuclear condensates and discovering roles for rRNA G-quadruplexes in nucleolar protein condensation. The lab received a Kaufman Foundation New Investigator Grant to explore RNA's role in directing transcription.

Advising and grants: Jonathan mentors a diverse team of PhD, Master’s, and undergraduate students. Notable advisees include Haoran Wang, Lydia Phillips, and Arth Banka. Current projects involve synthetic transcriptional condensates and bioinformatic discovery of RNA regulatory elements.

Labs and collaborations: The lab is equipped with state-of-the-art microscopy (e.g., Zeiss Lattice SIM 5) and collaborates with groups at CMU, Pitt, and NYU. Regular scientific events include the Steel City Condensate Club Symposium.