معرفی
Jonathan Doorn is the John L. & Carol E. Lach Endowed Chair and Professor of Pharmaceutical Sciences and Experimental Therapeutics at the University of Iowa College of Pharmacy, where he also serves as Department Chair. His research focuses on dopamine metabolism, mechanistic toxicology, and Parkinson's disease, with emphasis on environmental contaminant-induced neurodegeneration.
Education includes a BS from Calvin College (Michigan) and a Ph.D. in Toxicology from the University of Michigan, followed by postdoctoral training at the University of Colorado. He holds NIH membership on the NAL Study Section and received the prestigious John Doull Award in Toxicology.
Research interests include dopamine catabolism pathways, neurotoxic effects of polychlorinated biphenyls (PCBs), and development of neuroprotective agents. His work bridges mechanistic toxicology with drug discovery, particularly targeting dopamine-derived reactive aldehydes.
Publications (2024–2000) highlight studies on astrocyte mitochondrial toxicity from PCB metabolites, neuroprotective fraxinellone analogs, and dopaminergic neurotoxicity mechanisms. Key findings include the role of dopamine metabolites in oxidative stress and protein dysfunction.
Awards include recognition for teaching excellence and contributions to toxicology research. His lab focuses on translational research linking environmental exposures to neurodegenerative mechanisms, with applications to Parkinson's disease modeling and therapeutic development.
