Jonathan Bones

Dr. Jonathan Bones is an Associate Professor in the School of Chemical and Bioprocess Engineering at University College Dublin (UCD) and Principal Investigator of the Characterisation and Comparability Group at NIBRT. His research focuses on analytical methods for biopharmaceuticals, including liquid chromatography-mass spectrometry (LC-MS) for protein characterization, glycomics, and process optimization. He holds a BSc and PhD in Analytical Chemistry from Dublin City University. His work has been recognized through inclusion in the Medicine Maker Power List. He leads a team of 18 researchers, supported by SFI, EI, and industry partnerships.

Education:

• BSc in Analytical Science (Chemistry), Dublin City University
• PhD in Analytical Chemistry, Dublin City University

Research Interests: Development of advanced LC-MS platforms for glycomics, proteomics, and bioprocess analysis. Key areas include:

• Quantitative proteomics/metabolomics for bioprocess monitoring
• Liquid phase separations for complex bioanalysis
• Process analytical technology (PAT)

His group collaborates with ThermoFisher Scientific on analytical workflows for biopharmaceutical characterization.

Articles Trends: Recent work emphasizes analytical methods for AAV vector characterization, biosimilar comparability via MAM/iMAM, and process clearance of excipients. Over 126 publications highlight his contributions to biopharmaceutical quality control and process understanding.

Awards:

• Medicine Maker Power List (2023): Top 100 influential scientists in biopharmaceutical manufacturing and analysis

Advising & Grants:

• Supervises PhD students in bioprocessing and analytical chemistry
• Funding from Science Foundation Ireland (SFI), Enterprise Ireland (EI), and EU FP7
• Industry collaborations with ThermoFisher Scientific and Bristol Myers Squibb

Labs & Teams: Leads the Characterisation and Comparability Lab at NIBRT, focused on cutting-edge analytical tools for bioprocess development and product quality assurance.