جستجوی استاد راهنمای دانشگاهی

Sriram Subramaniamمشاهده پروفایل

استاد

• cryo-electron microscopy
• structural biology
• drug-design
• +۴ مورد دیگر

Sriram Subramaniam is a Professor in the Department of Biochemistry and Molecular Biology at the University of British Columbia (UBC) and holds the Gobind Khorana Canada Excellence Research Chair in Precision Cancer Drug Design. His research leverages cryo-electron microscopy (cryo-EM) to advance structural biology and drug design, focusing on protein dynamics and therapeutic target identification. Education: PhD in Physical Chemistry (1987) from Stanford University; MSc in Chemistry (1981) from Indian Institute of Technology, Kanpur. Subramaniam's interdisciplinary work combines cryo-EM with computational tools and molecular biology to study protein structures at atomic resolution. His lab has pioneered cryo-EM applications in precision medicine, including mapping small molecule drugs on patient-specific cancer mutants. Recent publications (2024-2022) highlight his contributions to understanding SARS-CoV-2 immune evasion, structural mechanisms of ATPases, and AI integration in structural biology. His research spans viral entry mechanisms, CRISPR systems, and neurodegenerative disease pathways. Scientific Awards: Gobind Khorana Canada Excellence Research Chair NIH Director’s Award for Scientific Excellence Fellow of the Biophysical Society Breakthrough Prize nomination Based at the Djavad Mowafaghian Center for Brain Health, Subramaniam leads the Program in Cryo-EM Guided Drug Design, contributing to over 177 peer-reviewed publications with a career h-index of 58 and citations exceeding 12,340.

Björn Corziliusمشاهده پروفایل

استاد

• Solid-state NMR Spectroscopy
• Dynamic Nuclear Polarization (DNP)
• Biomolecular Chemistry
• +۳ مورد دیگر

Prof. Dr. Björn Corzilius is a University Professor (W2) of Physical Chemistry at the University of Rostock, Germany, leading the Corzilius group. His research focuses on solid-state NMR spectroscopy, dynamic nuclear polarization (DNP), and applications in biomolecules and materials. He holds affiliations with the Leibniz Institute for Catalysis (LIKAT) and serves on multiple academic boards, including the transregional Collaborative Research Center TRR 386 and the journal Magnetic Resonance . Education: 1999: Studies of Chemistry, TU Darmstadt 2005: Diploma in Physical Chemistry (TU Darmstadt) 2008: Ph.D. in Physical Chemistry (TU Darmstadt) Research Interests: Solid-state NMR, DNP for sensitivity enhancement, paramagnetic metal ions, biomolecular dynamics, and method development. His work bridges theoretical and experimental approaches to advance structural and functional studies of complex systems like proteins, nucleic acids, and catalytic materials. Recent Article Trends: Focus on DNP applications in biomolecular interfaces, novel polarizing agents (e.g., Gd(III) complexes), and methodological advancements like serial polarization transfer and electron-decoupled DNP. Contributions span inorganic chemistry, materials science, and biophysical systems. Awards: Emmy Noether Fellowship (2012) Felix Bloch Lecture (2016) Regitze M. Vold Memorial Prize (2017) Best Ph.D. Supervision (2018) Grants & Labs: Principal Investigator of the Emmy Noether Group (2013–2019), now leading the DNP research team at the University of Rostock. Collaborates closely with LIKAT on catalytic and materials projects. His group actively develops open-access publishing platforms like Magnetic Resonance and hosts international conferences. Labs/Teams: The Corzilius group at the Institute of Chemistry (Rostock) specializes in NMR method development and applications. Associated with LIKAT for interdisciplinary catalysis research.

• Microbiology
• Immunology
• Bacterial Vaccines
• +۵ مورد دیگر

James B. Kaper is a Professor and Chair of the Department of Microbiology & Immunology at the University of Maryland School of Medicine. He serves as Vice Dean for Academic Affairs and previously held leadership roles as Senior Associate Dean (2014–2019) and Chair (2007–present). His research focuses on the molecular pathogenesis of diarrheagenic Escherichia coli and Vibrio cholerae , including vaccine development and bacterial-host interactions. Education: BS (1973) and PhD (1979) in Microbiology from University of Maryland; Postdoc in Molecular Pathogenesis at University of Washington (1979–1981) Dr. Kaper’s work has led to the creation of live attenuated cholera vaccines, including CVD 103-HgR, the first licensed recombinant bacterial vaccine. His lab investigates bacterial genetics, intestinal colonization, and immune system activation, particularly TLR5 response to V. cholerae flagellin. He has authored 303 peer-reviewed articles and 68 book chapters. His research has been funded continuously by NIAID since 1982. Key publications include foundational work on V. cholerae vaccines (1984), genomic structure (1998), and quorum sensing in EHEC/EPEC (1999). His lab’s recent studies focus on phosphotyrosine proteomics (2013) and pathogenicity island regulation (2007). Scientific awards: Fellow, American Academy of Microbiology (1994); NIH Merit Award (2004); ASM DC White Award (2019) Editorial roles: Editor-in-Chief, EcoSal (2006–present); Associate Editor, International Journal of Medical Microbiology (2000–present) As an academic leader, Dr. Kaper has mentored over 60 graduate students and postdoctoral fellows. He holds multiple patents for cholera vaccines and E. coli diagnostics, including U.S. Patents 4,935,364; 5,399,494; and 6,204,004. His lab at UMSOM combines basic science with translational applications for enteric disease prevention.

Bradley Olsenمشاهده پروفایل

استاد

• Polymer Science
• Materials Engineering
• Soft Condensed Matter Physics
• +۶ مورد دیگر

Bradley Olsen is a Professor of Chemical Engineering at the Massachusetts Institute of Technology (MIT), holding the Alexander and I. Michael (1960) Kasser Chair in Chemical Engineering. He is affiliated with MIT's School of Engineering and directs research in the Plastics and the Environment Program. His academic career spans over two decades with numerous prestigious appointments and recognitions. Olsen earned his S.B. from MIT in 2003 followed by a Ph.D. from the University of California Berkeley in 2007. His educational background is complemented by postdoctoral fellowships including NIH and Beckman Institute Postdoctoral Fellowships (2008-2009) and the Hertz Fellowship (2003-2007). Research Interests Professor Olsen's research focuses on designing materials to address important challenges while understanding the fundamental science necessary for materials design. His primary research areas include block copolymers, soft condensed matter physics, protein-based materials, and bioelectronics. His group specializes in polymer networks, protein-polymer conjugates, self-assembly phenomena, and sustainable polymer development. The research has significant implications for biomaterials, sustainable polymers, and advanced materials design. Publication Trends Analysis of Professor Olsen's recent publications reveals a strong focus on polymer network topology, protein-polymer conjugates, and sustainable materials. His work increasingly integrates computational methods with experimental approaches, particularly in polymer characterization and data science applications to materials science. Recent publications show growing emphasis on biodegradable polymers, polymer informatics, and biomedical applications of advanced materials. Scientific Recognition Professor Olsen has received numerous prestigious awards throughout his career, including: American Physical Society (APS) Fellow (2023) Fulbright Amazonia Scholar (2023) Alexander and I. Michael Kasser Chair in Chemical Engineering (2021) ACS Macro Letters/Biomacromolecules/Macromolecules Young Investigator Award (2021) AIChE Owens Corning Early Career Award (2019) American Physical Society Dillon Medal (2018) Alfred P. Sloan Research Fellow in Chemistry (2014) Advising and Funding Professor Olsen has secured significant research funding from multiple federal agencies including NSF, NIH, AFOSR, and DOE. His group has produced numerous high-impact publications across top journals in polymer science, materials science, and chemistry. He has advised multiple graduate students and postdoctoral researchers who have gone on to successful careers in academia and industry. The MIT OGE's Committed to Caring Honor (2019) recognizes his excellence in graduate student mentoring. Research Infrastructure Professor Olsen leads a research group with capabilities spanning polymer synthesis, protein engineering, materials characterization, and computational modeling. His lab maintains strong collaborations with other MIT departments, national laboratories, and international research institutions. The group participates in several interdisciplinary initiatives including the Plastics and the Environment Program and has developed significant data infrastructure for polymer science through projects like CRIPT and BigSMARTS.

Alexis Battleمشاهده پروفایل

دانشیار

• Genomics
• Machine Learning
• Computational Biology
• +۳ مورد دیگر

Alexis Battle is an Associate Professor at Johns Hopkins University with appointments in Biomedical Engineering , Computer Science , and Genetic Medicine (secondary). She directs the Malone Center for Engineering in Healthcare and serves as Deputy Director of the Data Science and AI Institute . Educated at Stanford University (PhD in Computer Science, 2013), Battle transitioned to academia after leadership roles at Google. Research Focus: Battle’s work bridges genomics and machine learning , emphasizing the impact of genetic variation on human health. Her lab develops tools like Watershed to predict functional effects of rare variants, aiming to enhance rare disease diagnosis. Key themes include non-coding DNA analysis , personalized genomics , and systems biology , with applications in cardiovascular disease and neurodegenerative disorders . Publications & Awards: Over 60 peer-reviewed articles in journals like Nature , Science , and Genome Biology , with recent emphasis on single-cell transcriptomics , multiomics integration , and telomere biology . Recipient of the President’s Frontier Award (2022), Microsoft Investigator Fellowship (2019), and Searle Scholar (2016). Scientific Awards: 2022 President’s Frontier Award 2019 Microsoft Investigator Fellowship 2019 Johns Hopkins Discovery Award 2017 Johns Hopkins Catalyst Award 2016 Searle Scholar Advising & Funding: Mentors 11 PhD students, 3 undergraduates, and postdoctoral fellows. Her research is funded by NIH, Searle Scholars, and institutional grants. The Battle Lab collaborates on projects like the GTEx Consortium , focusing on gene regulation and clinical genomics .

• Machine Learning
• Deep Learning
• AI Safety
• +۱۲ مورد دیگر

Tim G. J. Rudner is an Assistant Professor in the Department of Statistical Sciences at the University of Toronto, a Faculty Member at the Vector Institute, and a Title A Fellow at Trinity College, University of Cambridge. He was previously an Assistant Professor and Faculty Fellow at New York University. University: University of Toronto School: Faculty of Arts and Science Department: Department of Statistical Sciences Affiliation: Vector Institute, Trinity College (Cambridge) He holds a PhD in Computer Science and an MSc in Statistics from the University of Oxford, where he was advised by Yee Whye Teh and Yarin Gal, and a BS in Applied Mathematics and Economics from Yale University. PhD: Computer Science, University of Oxford MSc: Statistics, University of Oxford BS: Applied Mathematics and Economics, Yale University His research focuses on building robust, transparent, and trustworthy machine learning systems, particularly for high-stakes applications. He develops probabilistic models that improve generalization under distribution shifts, provide reliable uncertainty estimates, and enable fair and interpretable predictions. His work spans generative models, large language models, healthcare, and biomedical discovery. The recent publications highlight a strong trend toward function-space modeling, Bayesian regularization, and AI safety. Tim's work emphasizes principled uncertainty quantification, robustness to subpopulation and semantic shifts, and the development of frameworks for AI governance and specification. His research bridges theoretical advances with real-world applications, especially in safety-critical domains like medicine and defense. Tim has received numerous accolades including being named a Rhodes Scholar, Qualcomm Innovation Fellow, and 2024 Rising Star in Generative AI. He was awarded a $700,000 Foundational Research Grant and a $30,000 Apple Seed Grant for improving LLM trustworthiness. Rhodes Scholar Qualcomm Innovation Fellow AISTATS Notable Paper Award (2024) Outstanding Paper Award, ICLR GenAI4DM Workshop (2024) Apple Seed Grant ($30,000) Foundational Research Grant ($700,000) NeurIPS Spotlight Talk 2024 Rising Star in Generative AI He actively mentors students, particularly first-generation and low-income scholars, and has contributed to major policy frameworks including the OECD AI Classification Framework and a series of CSET issue briefs on AI safety. His work demonstrates a strong commitment to responsible AI development, combining technical rigor with societal impact. Tim leads research efforts at the intersection of machine learning theory and practical deployment, with ongoing projects in generative modeling, reliable LLMs, and AI governance. His lab produces high-impact work regularly published at top-tier conferences such as NeurIPS, ICML, and AISTATS.

Bradley D. Olsenمشاهده پروفایل

استاد

• Polymer Science
• Materials Engineering
• Soft Condensed Matter Physics
• +۴ مورد دیگر

Bradley D. Olsen is a full professor in the Department of Chemical Engineering at the Massachusetts Institute of Technology (MIT), where he leads research at the intersection of polymer science, soft matter physics, and bioengineering. His work focuses on designing materials for critical applications in biotechnology, hemostasis, and sustainable polymer development while advancing fundamental understanding of polymer network mechanics and self-assembly. Education: Ph.D. in Chemical Engineering, University of California Berkeley (2007) S.B. in Chemical Engineering, Massachusetts Institute of Technology (2003) Olsen's research spans protein-based materials, block copolymer phase behavior, and mechanochemical hydrogels. He has pioneered methods for quantifying polymer network topology, developing hemostatic nanoparticles, and creating bio-inspired materials for selective biomolecular transport and medical applications. His recent publications emphasize data-driven approaches to polymer characterization and educational outreach in materials science. Scientific Awards: American Physical Society (APS) Fellow (2023) Fulbright Amazonia Scholar (2023) Alexander and I. Michael Kasser Chair in Chemical Engineering (2021) ACS Macro Letters Young Investigator Award (2021) MIT Committed to Caring Honor (2019) AIChE Owens Corning Early Career Award (2019) APS Dillon Medal (2018) Kavli Emerging Leader in Chemistry (2017) ACS Polymer Division Fellow (2016) Camille Dreyfus-Teacher Scholar (2015) Alfred P. Sloan Research Fellow (2014) NSF Career Grant (2013) NIH Postdoctoral Fellowship (2008-2009) Hertz Fellow (2003-2007) Barry M. Goldwater Scholarship (2002) Olsen has received significant grant support including NSF Career (2013) and AFOSR (2012) awards. His teaching activities include innovative international outreach like the 2025 soccer-themed science camp in Brazil. The Olsen Group at MIT explores advanced materials with applications ranging from trauma care to sustainable polymers.

• Drug Delivery
• Nanomedicine
• Biopharmaceutics
• +۷ مورد دیگر

Dr. Shyh-Dar Li is a Professor and Tong Louie Chair in Pharmaceutical Sciences at the University of British Columbia's Faculty of Pharmaceutical Sciences, where he also serves as Chair of Nanomedicine and Chemical Biology. With a BSc in pharmacy from National Taiwan University (1998) and PhD in pharmaceutical sciences from UNC Chapel Hill (2008), followed by postdoctoral training at UC San Diego's Moores Cancer Center (2009), Dr. Li has established himself as a leading researcher in advanced drug delivery systems. His research focuses on developing innovative nanomedicine platforms for targeted delivery of biological therapeutics including peptides, proteins, antibodies, and nucleic acids. Dr. Li's laboratory has pioneered several novel drug delivery approaches, particularly in lipid-based nanoparticles, phospholipid-free vesicles, and polymer systems for cancer immunotherapy, pain management, and protein delivery. His work bridges fundamental nanotechnology with translational applications for difficult-to-treat diseases. Analysis of his recent publications reveals a strong emphasis on tumor microenvironment modulation, endosomal escape mechanisms for nucleic acid delivery, and non-invasive delivery routes for protein therapeutics. His research demonstrates increasing sophistication in nanocarrier engineering, with recent work incorporating machine learning approaches to optimize nanoparticle design and expanding into immunomodulatory therapies that harness the body's immune system to fight cancer. Scientific Recognition: 2014 AFPC New Investigator Award 2013 AAPS New Investigator Award in Pharmaceutics and Pharmaceutical Technologies 2013 CIHR New Investigator Award 2013 CSPS Early Career Award 2012 Prostate Cancer Foundation Young Investigator Award Dr. Li's research program has been consistently supported by major Canadian funding agencies including CIHR, NSERC, and MITACS. He actively collaborates across disciplines and accepts graduate students into his research program, focusing on cutting-edge approaches to overcome biological barriers in drug delivery. His laboratory, the Laboratory of Targeted Drug Delivery and Nanomedicine, serves as a hub for innovation in pharmaceutical nanotechnology.

Vikramaditya G. Yadavمشاهده پروفایل

دانشیار

• Biocatalysis
• Bioremediation
• Bioprocess engineering
• +۱۵ مورد دیگر

Vikramaditya G. Yadav is an Associate Professor at the University of British Columbia (UBC) in the Department of Chemical and Biological Engineering, Faculty of Applied Science. He directs the Master of Engineering Leadership (MEL) Program in Sustainable Process Engineering and leads the BioFoundry research group. Education: B.A.Sc., University of Waterloo (2007) Ph.D., Massachusetts Institute of Technology (2013) Postdoctoral Associate, Harvard University (2014) His research spans sustainable chemical manufacturing, metabolic engineering, and biotechnology. Key areas include: Designing biosynthetic enzymes for biomass valorization Developing bioremediation strategies for industrial water quality Creating innovative drug delivery systems and tissue engineering solutions Advancing synthetic biology for pharmaceutical and bioenergy applications His recent work focuses on ocular drug delivery, cannabinoid biosynthesis in E. coli, lignin-based nanoparticles for cancer therapy, and computational analysis of plant secondary metabolites. Collaborations with start-ups, industry, and medical labs drive innovation in Canada's bioeconomy. Professional Leadership: Chair, Biotechnology Division of the Chemical Institute of Canada Associate Editor, The Canadian Journal of Chemical Engineering He is affiliated with UBC's BioProducts Institute and contributes to project-based learning pedagogy.

Robert J. Hamersمشاهده پروفایل

استاد

• Electrochemistry
• Nanotechnology
• Materials Science
• +۹ مورد دیگر

Robert J. Hamers is a Professor of Chemistry and the Steenbock Professor of Physical Science at the University of Wisconsin-Madison . He serves as the Director of the Center for Sustainable Nanotechnology , a multi-institutional collaboration, and is a Senior Editor for Accounts of Chemical Research . Additionally, he co-founded the startup Silatronix, Inc. and leads the ACS/UW-Madison Bridge to the Chemistry Doctorate Program . B.S. in Chemistry, University of Wisconsin-Madison (1980) Ph.D. in Chemistry, Cornell University (1986) Hamers' research focuses on surface chemistry, nanotechnology, and renewable energy , with specific interests in electrochemical energy storage, photoelectron emission mechanisms, and environmental impacts of nanomaterials . His group develops ultra-stable surface chemistries for energy devices and investigates charge-transfer processes at material interfaces . Recent publications highlight advances in diamond-based materials , organosilicon electrolyte additives , and environmental fate of nanomaterials . Scientific recognitions include the Wisconsin Distinguished Professor title. His work bridges fundamental surface science with applied technologies through collaborations with academic institutions, national laboratories, and industry partners like Dow Chemical . The Hamers Group actively trains graduate students and postdoctoral researchers in multidisciplinary approaches.

Jörg F. Löfflerمشاهده پروفایل

استاد

• Bulk Metallic Glasses
• Metallic Biomaterials
• Magnetic Materials
• +۴ مورد دیگر

Jörg F. Löffler is a Full Professor of Metal Physics and Technology at the Department of Materials, ETH Zürich , where he has been since 2003. He previously served as Chairman of the Department (2010–2013) and holds Adjunct Professor positions at Tohoku University (Japan) and a Visiting Faculty role at Caltech. His research focuses on bulk metallic glasses , metallic biomaterials , and magnetic materials , combining synthesis, characterization, and applications in biomedical and structural contexts. Educations : Studied Physics and Materials Science at Saarland University (Germany), earned his doctorate at ETH Zurich and Paul Scherrer Institute on magnetism and neutron scattering (1997). Research Trends : Recent work explores additive manufacturing (e.g., laser powder bed fusion), biodegradable magnesium alloys for implants, and magneto-structural coupling in metallic glasses. Collaborative efforts integrate in situ analysis with computational modeling. Scientific Awards : International Magnesium Science and Technology Award (2023) MRS Fellow (2021) DGM 'Breakthrough' Prize (2016) Masing Memorial Prize (2005) ETH Zurich Medal (1998) Alexander von Humboldt Fellowship (1998-2001) Löffler advises the Department of Materials Science and Engineering at UC Davis and serves on editorial boards. His group at ETH Zürich investigates advanced metallic materials using synchrotron radiation and neutron scattering facilities.

Andrew Spakowitzمشاهده پروفایل

استاد

• Chromosomal organization and dynamics
• Protein self-assembly
• Polymer membranes
• +۷ مورد دیگر

Andrew Spakowitz is a Professor of Chemical Engineering, Materials Science and Engineering, and by courtesy, Applied Physics and Chemistry at Stanford University. He currently serves as the Senior Associate Dean for Research and Faculty Affairs and holds the Tang Family Foundation Chair of the Department of Chemical Engineering. His academic career at Stanford spans from Assistant Professor (2006-2014) to Associate Professor (2014-2020) and now Professor since 2020. Dr. Spakowitz earned his PhD in 2004, MS in 2001 from the California Institute of Technology, and his BS in Chemical Engineering from the University of Wisconsin, Madison in 1999. He completed postdoctoral training in Molecular and Cell Biology and Biophysics at UC Berkeley from 2004-2006. His research focuses on theoretical and computational approaches to understanding biological processes and complex materials. The Spakowitz lab addresses fundamental chemical and physical phenomena through four main research themes: chromosomal organization and dynamics, protein self-assembly, polymer membranes, and charge transport in conducting polymers. His group employs diverse theoretical and computational methods including analytical theory of semiflexible polymers, polymer field theory, continuum elastic mechanics, Brownian dynamics simulation, equilibrium and dynamic Monte Carlo simulations, and reaction-diffusion modeling. Analysis of his recent publications reveals a strong emphasis on epigenetics and chromatin dynamics, with significant work on DNA methylation patterns, nucleosome clustering, and chromosome organization. His research also extends to polymer physics applications in biological systems, particularly in respiratory diseases, water purification membranes, and bacterial phage interactions with human mucus. Tang Family Foundation Chair of the Department of Chemical Engineering Professor Spakowitz mentors several graduate students and postdoctoral scholars in the Chemical Engineering and Materials Science departments. His lab members work on diverse projects spanning from chromatin dynamics to polymer membranes for water purification. He teaches multiple courses including CHEMENG 120B (Energy and Mass Transport), CHEMENG 340 (Molecular Thermodynamics), CHEMENG 466 (Polymer Physics), and CHEMENG 467 (Physics of Biomacromolecules). The Spakowitz lab operates from Clark S295 at Stanford University, conducting theoretical and computational research that bridges chemistry, physics, biology, and engineering disciplines to address complex problems across multiple length and time scales.

Weiping Tangمشاهده پروفایل

استاد

• Targeted Protein Degradation
• PROTACs
• Medicinal Chemistry
• +۵ مورد دیگر

Weiping Tang is a Professor of Pharmaceutical Sciences and Chemistry at the University of Wisconsin-Madison, holding the Janis Apinis Professorship in the School of Pharmacy and the Vilas Distinguished Achievement Professorship. He also serves as Director of the Medicinal Chemistry Center at the School of Pharmacy and maintains a faculty appointment with the Department of Chemistry in the College of Letters and Science. Janis Apinis Professor of Pharmaceutical Sciences Vilas Distinguished Achievement Professor Director of Medicinal Chemistry Center Faculty Appointment with Department of Chemistry Dr. Tang received his B.S. in Chemistry from Peking University in 1997, M.S. in Chemistry from New York University in 1999, Ph.D. in Organic Chemistry from Stanford University in 2005, and completed a postdoctoral fellowship in Medicinal Chemistry, Chemical Biology and Drug Discovery at Harvard University in 2007. Dr. Tang's research program focuses on drug discovery for cancer, infectious diseases, and neurodegenerative disorders through three interconnected areas: Organic Synthesis (advancing glycoscience through novel carbohydrate synthesis technologies), Medicinal Chemistry (developing small molecules that selectively remove disease-associated proteins), and Chemical Biology (dissecting biological pathways using novel small molecule probes). His group operates as an interdisciplinary team where chemists and biologists collaborate closely on drug discovery projects, with particular emphasis on developing novel degraders for disease-causing proteins. Analysis of Dr. Tang's publication record reveals a significant shift toward targeted protein degradation technologies, particularly PROTACs and molecular glues, while maintaining strong foundations in carbohydrate chemistry. His most impactful recent work includes developing degraders for extracellular and membrane proteins (previously considered 'undruggable'), creating rapid synthesis platforms like Rapid-TAC and Rapid-Glue, and advancing understanding of ternary complex formation for novel PROTAC design. His research spans both chemical methodology development and therapeutic applications across multiple disease areas. Vilas Distinguished Achievement Professorship Janis Apinis Professorship Numerous high-impact publications in leading chemistry and pharmacology journals Editor's pick and hot paper designations for significant contributions Dr. Tang mentors a diverse team of graduate students, postdoctoral fellows, and staff scientists with expertise spanning synthetic chemistry, medicinal chemistry, carbohydrate chemistry, computational chemistry, biochemistry, and cell biology. His group has developed innovative platforms for the rapid synthesis of protein degraders and has made significant contributions to understanding the mechanisms of action for these novel therapeutics. Current research includes developing selective degraders for cancer targets like RIPK1, BRD4, and CARM1, as well as advancing delivery systems for clinical translation. The Tang Research Group maintains state-of-the-art facilities within the School of Pharmacy at UW-Madison, equipped for comprehensive chemical synthesis, compound characterization, and biological evaluation. The group actively collaborates with researchers across campus and with industry partners to advance discoveries toward clinical applications, with particular focus on cancer therapeutics and protein degradation technologies.

John M. Woodleyمشاهده پروفایل

استاد

• Biocatalysis
• Bioprocess Engineering
• Enzyme Technology
• +۶ مورد دیگر

John M. Woodley is a distinguished Professor in the Department of Chemical and Biochemical Engineering at the Technical University of Denmark (DTU), where he leads research at the PROSYS - Process and Systems Engineering Centre and contributes to the DTU Microbes Initiative. With over 30 years of experience, he has established himself as a leading expert in biocatalysis and bioprocess engineering, with research spanning both theoretical and experimental work across multiple scales. His primary research interests focus on the interface of bioprocess engineering, process chemistry, and reaction engineering. Dr. Woodley's work encompasses multi-step biocatalysis (including systems biocatalysis and flow chemistry), downstream processing from biocatalytic reactors and fermentations (including ISPR), modeling tools for bioprocess assessment (thermodynamics, kinetics, process simulation, economic evaluation), and bio-oxidations (including oxygen supply methods). His enzymatic investigations particularly target alcohol oxidases, carbohydrate oxidases, cytochrome P450s, Baeyer-Villiger monooxygenases, and transaminases. His research portfolio demonstrates consistent innovation in sustainable chemical production, with particular emphasis on enzymatic synthesis of pharmaceuticals and chemicals from renewable resources. Analysis of his recent publications reveals a strong focus on overcoming industrial implementation challenges, particularly regarding enzyme stability in various reactor environments, optimization of multi-enzyme systems, and scale-up methodologies for biocatalytic processes. Dr. Woodley actively supervises multiple PhD students and leads several significant research projects, including 'P450-based biocatalytic processes for the pharmaceutical industry' (2025-2028), 'Integrated model for up- and downstream bioprocess intensification' (2024-2027), and 'ENFACE: A tool for prediction of enzyme stability at gas-liquid interfaces' (2024-2027). His work has resulted in an impressive publication record of 781 research outputs across various formats, including journal articles, book chapters, and conference proceedings. His research group operates within the Department of Chemical and Biochemical Engineering at DTU, utilizing advanced facilities for biocatalysis research, including specialized reactor systems for studying gas-liquid interfaces, computational modeling resources, and laboratories for enzyme characterization and bioprocess development. Through his leadership in the PROSYS center, he contributes to DTU's strategic focus on sustainable process technologies and systems engineering.

Vadim Cherezovمشاهده پروفایل

استاد

• Membrane Protein Structure and Function
• G Protein-Coupled Receptors (GPCRs)
• Lipid-Protein Interactions
• +۳ مورد دیگر

Vadim Cherezov, the Ester Dornsife Chair in Biological Sciences and Professor at the University of Southern California (USC), leads groundbreaking research in membrane protein structure and function. Affiliated with the Bridge Institute, Department of Chemistry, and Michelson Center for Convergent Bioscience, his work focuses on GPCRs, ion channels, and transporters—critical targets for drug discovery. His team leverages advanced techniques like Lipidic Cubic Phase (LCP) and Serial Femtosecond Crystallography (SFX) at XFEL facilities to solve high-resolution structures under physiological conditions. Institutional Affiliations: Bridge Institute, USC Michelson Center, Department of Chemistry, Department of Pharmacology and Pharmaceutical Sciences. Key Collaborations: Katritch Lab, Kuhn Lab, NIH, European XFEL. His research explores the role of lipids in modulating GPCR function, addressing diseases like Alzheimer’s, diabetes, and cancer. By solving the structure of the A 2A adenosine receptor via sulfur SAD phasing at XFEL, Cherezov’s lab demonstrated de novo phasing without heavy atoms. This breakthrough enables structural studies of previously intractable membrane proteins. Scientific Awards & Grants: NIH R01 GM108635, U54 GM094618, U54 GM094599, R01 GM095583 Science Signaling Breakthroughs of the Year (2014) Cherezov mentors a dynamic team, including postdocs (e.g., Dong-Gyun Kim), graduate students (e.g., Behnaz Davoudinasab), and alumni (e.g., Benjamin Stauch at Eli Lilly, Nairie Michaelian at Genentech). His lab’s publications span Nature , Science , and Cell , with recent work on Science Advances (2025) addressing ABEL-FRET for GPCR dynamics.