Jonas Fuxe

Jonas Fuxe is a Professor and Head of the Department of Laboratory Medicine at Karolinska Institutet. His research focuses on cellular plasticity linking chronic inflammation and cancer, particularly mechanisms of tissue remodeling, epithelial-mesenchymal transition (EMT), and lymphatic metastasis.

• Affiliated with: Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet
• Education: Doctor of Philosophy (2001), Docent (2011)

Research interests include:

• Vascular Remodeling: Role of angiopoietins and Tie2 signaling in inflammatory and lymphatic vessel changes.
• Epithelial-Mesenchymal Transition (EMT): TGF-β1-induced EMT and its link to tumor invasion and metastasis.
• Tumor Microenvironment: Immune cell interactions, EMT-driven chemotaxis, and sex dimorphism in cancer progression.

Recent publications highlight:

• EMT and lymphatic metastasis synergy via podoplanin-CCR7.
• TGF-β1-induced interleukins (IL7/IL15) in breast cancer.
• Adaptive NK cell immune memory in ovarian cancer.
• Machine learning models for organelle dynamics in EMT.

Students and alumni include:

• Current PhD Students: Francesca Gatto, Wenyang Shi
• Former Postdocs: Mei-Fong Pang (Princeton), Jill Johnson (Imperial College London)
• Former PhD Students: Tove Berg, Vedrana Tabor, Sandra Travica

Contact: jonas.fuxe@ki.se