معرفی
John M. Sedivy is the Hermon C. Bumpus Professor of Biology and Director of Brown University's Center for the Biology of Aging. A faculty member since 1996, he holds appointments in the Department of Molecular Biology, Cell Biology and Biochemistry. His career spans groundbreaking work in cell cycle regulation, oncogene biology, and cellular aging.
- Education: PhD in Molecular Biology (Harvard, 1985), BSc (University of Toronto, 1978)
Sedivy's research focuses on cellular senescence, epigenetic regulation, and transposable element dynamics in aging. He pioneered single-cell senescence assays and epigenetic aging studies, notably demonstrating age-associated heterochromatin expansion and transposable element activation in somatic tissues.
His 15+ recent publications highlight themes in telomere biology, chromatin changes during aging, Myc signaling, and bioinformatics approaches to gene network analysis. Key contributions include first in vivo quantification of cellular senescence in primates (2006) and epigenetic clocks for aging (2011).
- Scientific Awards:
- NIH Merit Award (2009)
- Glenn Award for Aging Research (2011)
- Hermon C. Bumpus Chair (2006)
- Ellison Senior Research Scholar (2007)
As an administrator, he chaired Brown's Department of Molecular Biology, Cell Biology and Biochemistry and founded its Genomics and Proteomics Center. He served on NIH CMAD study section (2003-2012) and co-edited Aging Cell (2006-2012). His lab's work has been continuously funded by NIH since 1989, including a 10-year MERIT award (R37 AG016694).
