معرفی
Jan Padeken is a Group Leader at the Institute of Molecular Biology (IMB) in Mainz since 2022. His research focuses on epigenetic regulation through histone H3 lysine 9 methylation (H3K9me), exploring its roles in heterochromatin establishment, genome stability, and tissue integrity.
- Education:
- PhD in Cell Biology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg (2013)
- Diploma in Biology, Albert-Ludwigs University, Freiburg (2009)
- Vordiploma in Biology, RWTH Aachen University (2006)
His work investigates how persistent genotoxic stress alters heterochromatin dynamics in C. elegans, linking these changes to cancer, ageing, and Cockayne syndrome. He employs genetic tools, sequencing, and quantitative microscopy to analyze acute and long-term epigenetic responses.
Recent research trends highlight his focus on:
- Pathways controlling H3K9 methylation
- Transposable element silencing
- Epigenetic stress adaptation
- Heterochromatin propagation
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