John L. Rubinstein

John L. Rubinstein is a Professor in the Department of Biochemistry and Medical Biophysics at the University of Toronto. He leads a research group at the Research Institute of The Hospital for Sick Children, focusing on electron cryomicroscopy (cryo-EM), structural biology, and macromolecular assemblies.

• Education:
  • B.Sc., University of Guelph (1998)
  • Ph.D., Cambridge University (2002), supervised by Sir John E. Walker and Dr. Richard Henderson
  • Postdoctoral Research Associate at MRC Laboratory of Molecular Biology and National Cancer Institute of Canada

His research explores the structure and function of macromolecular machines, particularly mitochondrial ATP synthase, V-ATPase, and bacterial toxins, using cryo-EM and computational tools. Recent work includes drug interactions in tuberculosis and high-speed cryo-EM specimen preparation techniques.

His scientific awards include the Biophysical Society of Canada’s National Lecturer (2021), Stockholm University’s honoris causa (2020), Canada Research Chair (2014-2021), and the Burton Medal (2013).

• Lab Members:
  • Postdoctoral Fellows: Yazan Abbas, Justin Di Trani, Yong Zi Tan
  • Graduate Students: Yingke Liang, Hui Guo, Thamiya Vasanthakumar, Hanlin Wang, David Yanofsky
  • Research Project Coordinator: Stephanie Bueler
  • Microscopy Facility Manager: Samir Benlekbir
  • Collaborator: Carol V. Robinson