معرفی
John Konhilas is a Professor in the Department of Physiology at the University of Arizona. His research focuses on cardiovascular physiology with a particular emphasis on menopausal health impacts, probiotic therapies, angiotensin peptide biology, and neurovascular dysfunction. He explores mechanisms underlying cardiovascular disease vulnerability in postmenopausal women, leveraging mouse models to study gut-heart crosstalk, myocardial remodeling, and probiotic interventions.
His work integrates molecular biology techniques (transcriptomics/proteomics), drug development (angiotensin analogs), and big data analysis to identify menopausal phenotypes. He investigates novel treatments for vascular cognitive impairment and HFpEF through angiotensin receptor agonists (e.g., PNA5) and probiotic species like Bifidobacterium.
Recent studies highlight synergistic therapies combining surgical techniques (transmyocardial revascularization) with biomaterials (human placental membrane) and advanced preservation solutions for organ transplantation. His publications emphasize sex-dimorphic cardiovascular responses, estrogen-independent mechanisms, and biomarker development for neurodegeneration (neurofilament light protein, p-tau181).
