معرفی
Dr. Pascale Charest is an Associate Professor in the Department of Molecular and Cellular Biology at the University of Arizona, with affiliations in the Cancer Bio GIDP, Bio5 Institute, and the Department of Chemistry and Biochemistry. She leads the Charest Lab, which focuses on understanding the signaling pathways controlling chemotaxis and cell migration, particularly in Dictyostelium discoideum and human cancer cells. Her interdisciplinary research combines genetic, biochemical, and computational approaches.
Education: Ph.D. in Molecular and Cellular Biology (implied by academic rank).
Research Interests: Chemotaxis mechanisms, directed cell migration, Ras and Rap1 signaling pathways, mTORC2 regulation, and metastasis prevention. The lab uses Dictyostelium as a model organism and collaborates with Dr. Wouter-Jan Rappel on quantitative models of chemotaxis.
Recent Articles Trends: Recent work emphasizes Ras-mTORC2 signaling, oncogenic KRAS mutations in lung cancer, and caffeine’s effects on signaling pathways. Collaborations integrate live-cell imaging and proximity labeling techniques.
- Awards: NSF-MCB 2426002, NIH-NIGMS grants, and individual awards like the Galileo Circle and ABRCMS Poster Award.
- Advising & Grants: Mentors over 40 students, including graduates like Douglas Swango and Olivia Hajdys. Funded by NIH, NSF, and industry grants.
Labs/Teams: The Charest Lab collaborates across departments and institutions, hosting high school interns and graduate students in diverse programs.
