معرفی
John Engen is a Distinguished Professor and James L. Waters Chair in Analytical Chemistry at Northeastern University's Department of Chemistry and Chemical Biology, within the College of Science. His laboratory specializes in bioanalytical chemistry and mass spectrometry, particularly hydrogen exchange mass spectrometry (HX MS), to study protein conformation, dynamics, and interactions. His research spans disease-related signaling pathways, including cancer kinases, viral proteins, and membrane-associated proteins. Engen's work also involves methodological advancements in HDX-MS for complex biological systems. He collaborates with institutions like Harvard Medical School and Dana-Farber Cancer Institute on projects such as Myostatin activation and BTK inhibitor resistance mechanisms.
He holds leadership roles in the Barnett Institute for Chemical & Biological Analysis and directs the Engen Lab. His research interests include understanding protein conformational changes in disease contexts, optimizing mass spectrometry techniques, and applying these tools to pharmaceutical development. Engen’s contributions have been featured in journals like Science and Nature, and he has advised students on topics like chaperone-assisted protein folding and integrin biology. His lab website and Google Scholar profile showcase extensive publications and methodological innovations in the field.
