معرفی
John-Demian (JD) Sauer is an Associate Professor in the Department of Medical Microbiology and Immunology at the University of Wisconsin–Madison, where he leads an active research laboratory focused on bacterial pathogenesis and host immune responses. His work centers on the intracellular pathogen Listeria monocytogenes, using genetic and immunological approaches to dissect mechanisms of virulence and immunity.
Research Interests: Dr. Sauer's research explores how intracellular pathogens parasitize host cells and how the host recognizes and responds to infection. His lab investigates bacterial metabolism, immune signaling pathways (including inflammasome and type I interferon), and the development of long-term protective immunity. A key focus is understanding how pathogen virulence strategies can be leveraged for antimicrobial and immunotherapeutic development.
Publication Trends: Recent publications highlight the critical role of bacterial metabolism—particularly phosphotransferase systems and c-di-AMP signaling—in L. monocytogenes virulence and host immune modulation. Studies employ transposon mutagenesis, murine infection models, and metabolic profiling to uncover novel virulence mechanisms and host recognition pathways.
Scientific Awards:
- No awards explicitly mentioned in the provided text.
Advising and Grants: Dr. Sauer actively mentors graduate students and postdoctoral fellows, including Matt Freeman, Noah Eral, Abby DeBrine, Chris Lee, Dr. Kevin Parducho, and Dr. Alyssa Brokaw. His lab has secured competitive funding, including a recent R21 grant from NIAID on the role of Prostaglandin E2 in CD8+ T-cell priming during Listeria infection.
Labs and Teams: The Sauer Lab is based in the Microbial Sciences Building at UW–Madison and operates as a collaborative research team utilizing genetics, immunology, and microbiology techniques to study host-pathogen interactions. The lab frequently collaborates with other research groups, such as the Huynh Lab and Huttenlocher Lab, indicating strong interdisciplinary engagement.
