معرفی
Dr. John Clarke is an Associate Professor in the Department of Pharmaceutical Sciences at Washington State University's College of Pharmacy and Pharmaceutical Sciences. He serves as Chair of his department and teaches courses in pharmacology and toxicology for both PhD (Pharmaceutical Sciences and Molecular Medicine) and Doctor of Pharmacy (PharmD) programs, including Integrated Pharmacology II and Fundamentals of Toxicology.
- PhD in Molecular and Cellular Biology, Oregon State University
- BSc in Biology, Brigham Young University-Idaho
Dr. Clarke's research focuses on inter-individual variability in xenobiotic exposures and toxicities, particularly in the context of nonalcoholic fatty liver disease (NAFLD) and natural product-drug interactions. His work investigates how genetic, disease-related, and dietary factors influence drug metabolism and toxin response to improve precision medicine approaches.
Publications analysis shows consistent focus areas:
- Drug transporter mechanisms
- NAFLD/NASH interactions with xenobiotics
- Environmental toxin (microcystin-LR) effects
- Natural product-drug interactions (silymarin, goldenseal)
- Metabolomic and genomic profiling
- Pharmacokinetic modeling
Dr. Clarke leads multiple NIH-funded research projects including:
- R00ES024455: Microcystin-LR toxicity in NASH
- R21AT011101: Natural product-drug interactions in enteric/hepatic transport
- R56AT010650: Xenobiotic interactions in chronic disease
- 1R01ES032558: Microcystin-induced hepatocellular carcinoma in NASH
His lab team includes 18 researchers ranging from undergraduate interns to postdoctoral fellows, with expertise in molecular biology, pharmacology, and toxicology.
