Jiyoung Moon

Jiyoung Moon is an Associate Research Scientist in the Department of Cardiovascular Medicine at Yale School of Medicine, Yale University. Her research focuses on metabolic disorders, obesity, diabetes, and cardiovascular health, with particular emphasis on molecular mechanisms regulating lipid metabolism, adipose tissue biology, and AMPK signaling pathways. She explores the roles of myokines, adipokines, and enzymatic pathways like arginase in metabolic dysfunction.

Her work combines experimental models with translational approaches, investigating therapeutic potentials of natural extracts (e.g., Semen cuscutae), biomaterial scaffolds for tissue engineering, and genetic factors influencing cardiometabolic traits in Korean populations. Key areas include the regulation of brown/beige adipose thermogenesis, bile acid-mediated nanoparticle transport, and AMPK-driven glucose homeostasis.

Moon's publications reveal a trend toward systems biology approaches, integrating metabolomics, genetic epidemiology, and drug development. She has contributed to understanding the dual roles of arginase in obesity-associated inflammation and endothelial dysfunction, as well as the protective effects of meteorin-like peptides in diabetes. Her research bridges basic science and clinical applications, addressing metabolic syndrome and cardiovascular disease mechanisms.

Her studies utilize both in vivo models (diet-induced obesity mice) and in vitro systems, with a strong focus on translational outcomes like novel therapeutic targets and diagnostic biomarkers. Current work may involve further exploration of adipocyte signaling pathways and the development of targeted interventions for metabolic disorders.