معرفی
Jichun Xie is an Associate Professor in both the Department of Biostatistics & Bioinformatics and the Department of Computer Science at Duke University. He is also affiliated with the Duke Cancer Institute and the Duke Center for Statistical Genetics and Genomics. His research spans computational biology, genomics, and statistical methods for single-cell data and rare variant analysis.
Education:
- Ph.D. in Biostatistics, University of Pennsylvania (2011)
Research Focus: Dr. Xie develops computational frameworks for single-cell RNA sequencing analysis, rare variant association studies, and integrative genomics. His work bridges statistical inference with biological discovery, particularly in cancer immunology, aging, and immune disorders.
Publication Trends: Recent papers emphasize single-cell data analysis (e.g., SifiNet, B-Lightning), rare variant mapping (DYNATE), and immune-genomic interactions in chronic GVHD and cancer. Methodologically, he pioneers hierarchical multiple testing and co-expression graph topologies.
Grants:
- Duke Program of Training in Pulmonary Research (PROSPER), NIH/NHLBI (2022-2026)
- New computational methods for rare variant subregion detection, NIH/NHGRI (2022-2026)
- Training Program in Bioinformatics at the Intersection of Cancer Immunology and Microbiome, NIH/NCI (2020-2026)
Labs and Teams: Dr. Xie leads the Xie Lab, which actively trains students and researchers in computational methods. The lab collaborates with immunologists and oncologists, producing tools like DART and TEAM for biomedical analysis.
