معرفی
Jesse D. Bloom is an Associate Professor in Microbiology at the University of Washington and an Assistant Member at the Fred Hutchinson Cancer Research Center (Fred Hutch). He leads the Bloom Lab, which integrates experimental and computational approaches to study molecular evolution, viral proteins, and immune interactions. The lab is affiliated with the UW Genome Sciences Department and the Howard Hughes Medical Institute (HHMI).
- Research Focus: Evolution of viruses (influenza, SARS-CoV-2, RSV), deep mutational scanning, antigenic drift, and antibody escape mechanisms.
- Key Tools: Development of high-throughput assays like sequencing-based neutralization and yeast-display escape calculators.
Recent Publications highlight trends in viral evolution, including pleiotropic constraints on hemagglutinin stability and the impact of immune imprinting on SARS-CoV-2 antibody specificity. His work informs vaccine design (e.g., stabilized H5 HA) and tracks antigenic changes across pathogens.
Awards: HHMI Investigator. Students: Mentions graduate researchers like Caleb Carr, Caroline Kikawa, and Tim Yu. Lab Affiliation: Based in Fred Hutch's Basic Sciences Division, with collaborative ties to UW's Microbiology and Genome Sciences departments.
