معرفی
Dr. Frederick "Erick" Matsen is a Professor in the Public Health Sciences Division at Fred Hutchinson Cancer Research Center, where he serves as Associate Program Head of the Herbold Computational Biology Program. He is also an Affiliate Associate Professor of Genome Sciences and Statistics at the University of Washington and a Howard Hughes Medical Institute Investigator. Dr. Matsen leads the Matsen Lab, which focuses on computational approaches to evolutionary biology and immunology.
Dr. Matsen's research centers on computational biology, particularly developing algorithms to analyze biological data from DNA sequencing of viruses, immune cells, and complex environmental samples. His team works on phylogenetic methods, evolutionary tree construction, and software development for computational biology. Key research areas include Bayesian phylogenetics via optimization, phylodynamics with many sequences, antibody sequence analysis, and learning immune mechanisms from receptor sequences. His work bridges mathematics, computer science, and biological discovery, with applications to HIV, SARS-CoV-2, and other pathogens.
The Matsen Lab has developed numerous influential resources including phyloseminar.org, B-T.CR, and phylobabble.org. Recent publications demonstrate a strong focus on machine learning applications in phylogenetics, antibody evolution analysis, and computational approaches to viral evolution. His team's work has significant implications for understanding immune responses to pathogens and developing better vaccines and treatments.
- Howard Hughes Medical Institute Investigator (2021-present)
- Howard Hughes Medical Institute-Simons Foundation Faculty Scholar
Dr. Matsen maintains an active mentoring program, with an impressive track record of trainees securing tenure-track faculty positions. His lab fosters a collaborative environment where biologists learn analytical tools and computational scientists work directly with biological problems. Current projects include developing computational methods for outbreak control and analyzing antibody responses to SARS-CoV-2 using phage-immunoprecipitation sequencing.
The Matsen Lab operates within Fred Hutch's collaborative ecosystem, including membership in the Immunotherapy Integrated Research Center, Pathogen-Associated Malignancies Integrated Research Center, and Translational Data Science Integrated Research Center. The lab has recently moved to the Lake Union Steam Plant facility, specifically designed to facilitate collaboration between clinical researchers, data scientists, and evolutionary biologists.
