معرفی
Jennillee Wallace, PhD, is an Assistant Professor in the Department of Microbial Pathogens and Immunity at Rush Medical College, Rush University, Chicago. Her research centers on understanding how myeloid cells contribute to HIV-induced inflammation and associated comorbidities, including HIV-associated neurocognitive disorders (HAND), through the investigation of signaling pathways such as Wnt/β-catenin.
- PhD, Rush University Graduate College
- MS, Rush University Graduate College
- BA, Lake Forest College
Her research focuses on the role of myeloid cells—particularly macrophages and monocytes—in HIV pathogenesis, with a strong emphasis on how antiretroviral therapies impact cellular function. She investigates how Wnt signaling modulates immune cell behavior, HIV latency, and neuroinflammation. Her work also extends to understanding cytokine dysregulation in astrocytes and impaired wound healing in diabetic conditions, highlighting her interdisciplinary approach at the intersection of immunology, virology, and neurobiology.
Her recent publications (2014–2024) reflect a consistent focus on HIV immunology and cellular signaling. Key themes include mitochondrial dysfunction induced by antiretrovirals, β-catenin’s role in HIV latency and reactivation, astrocyte infection and viral egress from the CNS, and immune regulation in chronic inflammatory conditions. Her work appears in high-impact journals such as PLoS Pathogens, Journal of Immunology, and Antimicrobial Agents and Chemotherapy, demonstrating strong translational and mechanistic insights.
While no specific awards are listed in the provided text, her work has been widely recognized through citations, media coverage, and inclusion in news outlets, blogs, patents, and Wikipedia, indicating significant scientific impact.
Jennillee Wallace actively collaborates with leading researchers such as Dr. Lena Al-Harthi and contributes to a vibrant research environment at Rush University. She advises no named students in the provided material and leads no explicitly described lab or team, but her publication record indicates active mentorship and collaboration. Her ongoing research suggests future directions in targeting signaling pathways to mitigate HIV-related inflammation and comorbidities.
