Marc S Horwitz

Marc S. Horwitz is a Professor at the University of British Columbia, affiliated with the Faculty of Science and the Department of Microbiology and Immunology. His research focuses on viral-induced immune dysregulation in chronic diseases like Type 1 Diabetes, Multiple Sclerosis, and Haemorrhagic Fevers.

• Department: Microbiology and Immunology
• Laboratory: Horwitz Lab
• Research Group: Infection, Immunity, and Inflammation
• Chair: Sauder Chair of Pediatric Virology

Horwitz investigates how viral infections trigger autoimmune responses through mechanisms like enterovirus-induced dysbiosis, age-associated B cell pathogenicity, and type I interferon signaling imbalances. His work on coxsackievirus and γHV68 models has revealed critical pathways linking viral latency to chronic inflammation.

Key publication trends include studies on:

• Epstein-Barr virus and multiple sclerosis pathogenesis
• Dietary fiber interventions for Th1-mediated autoimmunity
• Age-associated B cells in latent viral infections
• Gene dosage effects on β-cell autoimmunity
• Toll-like receptor signaling in diabetogenic viruses

His research has significant implications for understanding the role of environmental triggers in autoimmune disease progression.