معرفی
Jeffery S. Cox is a Professor in the Department of Molecular & Cell Biology at the University of California, Berkeley, holding the C.H. Li Chair of Biochemistry and Molecular Endocrinology. His research focuses on understanding the symbiotic relationship between Mycobacterium tuberculosis and its human host to develop novel therapeutic strategies for tuberculosis (TB) eradication.
- Research Expertise: Host-pathogen interactions, innate immunity, host-directed therapy, genetics, proteomics, and transcriptional profiling.
Professor Cox's lab investigates how macrophages intrinsically control bacterial viability and shape immune responses, challenging conventional wisdom by demonstrating that macrophages can discriminate virulent from non-virulent M. tuberculosis through advanced techniques like CRISPR genetics and mass spectrometry-based proteomics. This work aims to harness macrophage pathways for therapeutic intervention.
The lab's research highlights unconventional strategies targeting innate immune responses, particularly macrophage activation, as a promising approach to combat TB infection. This aligns with their focus on breaking the co-evolutionary ties between M. tuberculosis and humans.
