Jeffery Cox

Jeffery Cox is the C.H. Li Chair of Biochemistry and Molecular Endocrinology and a Professor of Immunology and Molecular Medicine at the University of California, Berkeley. His research focuses on understanding the symbiotic-like relationship between Mycobacterium tuberculosis and its human host, aiming to develop novel strategies to combat tuberculosis (TB). His work employs cutting-edge techniques including CRISPR genetics and mass spectrometry-based proteomics to study macrophage responses and bacterial virulence mechanisms.

Key research interests include the role of macrophages in controlling TB infection, innate immune mechanisms, type VII secretion systems in M. tuberculosis, and the activation of autophagy and interferon pathways. His lab has discovered that macrophages can distinguish virulent from non-virulent strains early in infection, shaping immune responses and bacterial growth outcomes.

Publications highlight advancements in understanding secretion systems, DNA sensing pathways, and the role of ubiquitin ligases like parkin in pathogen resistance. The Cox Lab seeks to translate these findings into therapeutic approaches targeting host or pathogen factors to eliminate persistent TB infections.

Advising and grants are not explicitly detailed in the provided text, though his research has been supported by institutions like the NIH (indicated by PMCID entries). The Cox Lab operates from its dedicated website (http://www.coxlab.berkeley.edu/), maintaining a focus on interdisciplinary approaches to global health challenges posed by TB.