Jeffery A Goldstein

Jeffery A Goldstein, MD, PhD is an Associate Professor in the Department of Pathology at Northwestern University Feinberg School of Medicine, where he serves as Director of Perinatal Pathology with additional appointments in Autopsy Pathology. He is an attending physician at Northwestern Memorial Hospital with clinical and teaching responsibilities in perinatal and autopsy pathology.

His educational background includes:

• PhD: University of Chicago (2012)
• MD: University of Chicago (2014)
• Residency: Vanderbilt University, Anatomic Pathology (2017)
• Fellowship: Northwestern University, McGaw Medical Center (Lurie Children's Hospital), Pediatric Pathology (2018)

Dr. Goldstein is an early-stage investigator focusing on maternal-child health with particular expertise in placental pathology. His research integrates bioimaging, informatics, and machine learning to transform placental examination from a specialized, resource-intensive process into a widely accessible diagnostic tool. He develops AI algorithms that can analyze placental photographs and microscopic slides to detect abnormalities associated with infection, neonatal sepsis, and other pregnancy complications. His work bridges computational science with clinical pathology to address the significant gap that less than 20% of placentas receive clinical examination despite their diagnostic value for future maternal and child health.

His research portfolio includes multiple innovative projects applying machine learning to placental diagnosis, deep phenotyping, and quantitative description of placental features in health and disease. His recent publications demonstrate applications of deep learning for fetal inflammatory response diagnosis, machine learning assessment of gestational age, and analysis of placental lesions in gestational diabetes.

Dr. Goldstein holds board certifications in Anatomic Pathology and Pediatric Pathology from the American Board of Pathology. His clinical work focuses on microscopic examination of placental slides, which forms the foundation of his research.

He is affiliated with several research centers including the Center for Reproductive Science, the Institute for Artificial Intelligence in Medicine (specifically the Center for Computational Imaging and Signal Analytics in Medicine), and the Northwestern University Clinical and Translational Sciences Institute (NUCATS). His work has been featured in Northwestern Medicine news regarding AI applications for placental analysis to detect neonatal and maternal problems.