معرفی
Jeff Coleman, PhD, is a Researcher in the Department of Cell Biology at Yale School of Medicine, affiliated with the Rothman Lab. His research focuses on molecular mechanisms of synaptic vesicle release, membrane protein organization, and SNARE complex assembly. He holds a BA from the University of California, Berkeley (1989) and a PhD from the University of Melbourne (2002). Coleman collaborates extensively with researchers like Shyam Krishnakumar and Frederic Pincet, investigating calcium signaling, membrane fusion, and protein oligomerization. His work employs advanced techniques such as single-molecule imaging and native mass spectrometry to study synaptic processes. Recent studies include roles of diacylglycerol in synaptic vesicle priming and the structural dynamics of synaptotagmin oligomers.
- Education: PhD, University of Melbourne (2002); BA, UC Berkeley (1989)
- Key Research Themes: SNARE complex assembly, membrane protein oligomerization, calcium-dependent exocytosis, synaptic vesicle trafficking
Publications highlight his contributions to understanding molecular determinants of complexin function and the development of novel platforms like the 'plasma membrane-on-a-chip' for single-molecule studies. Coleman’s work bridges biochemistry and neuroscience, with implications for neurodegenerative diseases and cellular signaling.
