معرفی
Dr. Kirill Grushin is a Research Scientist in Cell Biology at Yale School of Medicine's Rothman Lab. His work focuses on molecular mechanisms of synaptic transmission using biochemical reconstitution approaches.
Research investigates: 1) Munc13-1 chaperone oligomerization in vesicle priming, 2) Diacylglycerol signaling in neurotransmitter release, and 3) Structural transitions during synaptic vesicle fusion. Recent publications (2023) establish cooperative binding mechanisms in vesicle recruitment.
Methodologies include cryo-electron microscopy, lipid nanotube assembly, and nanodisc technologies for structural analysis. Current projects examine SNARE complex dynamics and calcium-triggered membrane fusion.
Dr. Grushin mentors PhD students in electron engineering and collaborates on NIH-funded studies of vesicle trafficking mechanisms.
