معرفی
Frederic Pincet, PhD is an Associate Research Scientist in the Department of Cell Biology at Yale School of Medicine. He leads research in membrane dynamics, synaptic vesicle fusion, and protein-lipid interactions within the Rothman Lab. His work combines biophysical techniques with cell biology to study fundamental mechanisms of membrane remodeling and fusion processes.
Education: Received his PhD from École Normale Supérieure de Paris (1994).
Research Interests:
- SNARE protein complexes and their role in exocytosis
- Membrane curvature and tubulation mechanisms
- Collagen secretion pathways via intercompartmental continuities
- α-synuclein-induced membrane dysfunction in neurodegenerative diseases
- Development of photosensitive nanoprobes for vesicle isolation
Recent Trends in Publications:
His 2024 work focuses on synaptotagmin oligomerization dynamics and novel extracellular vesicle isolation techniques. Recent studies highlight dual-ring SNAREpin machinery regulation and membrane protein interactions in reduced dimensions. Ongoing research explores collagen secretion mechanisms and mitochondrial membrane control via apolipoproteins.
Labs/Teams: Active contributor to the Rothman Lab, collaborating closely with James E. Rothman (Nobel Laureate in Physiology/Medicine).
