معرفی
Jason D Hinman is a Professor-in-Residence in the Department of Neurology at UCLA's David Geffen School of Medicine, where he also serves as Vice Chair of Research and directs the Stroke Program at the West Los Angeles VA Medical Center. His NIH-funded research program investigates stroke, dementia, white matter injury, and neural repair mechanisms, with emphasis on neurovascular unit dysfunction and biomarker discovery.
Education includes a B.A. in Psychology from Case Western Reserve University (1999), M.D./Ph.D. in Medicine/Molecular Medicine from Boston University (2007), Internal Medicine residency at Cedars-Sinai (2008), and Neurology/Neurorehabilitation training at UCLA (2011-2014).
Research focuses on three interconnected themes: (1) Neurovascular injury mechanisms in stroke and dementia, particularly white matter damage and blood-brain barrier dysfunction; (2) Molecular repair pathways involving oligodendrocytes, astrocytes, and axonal regeneration; (3) Translational biomarker development for vascular cognitive impairment using imaging and fluid biomarkers. Current NIH grants support studies on intracranial atherosclerosis hemodynamics, tauopathy-induced vascular dysfunction, and white matter repair.
Recent publications demonstrate strong emphasis on vascular contributions to cognitive decline, with recurring themes in endothelial pathobiology, inflammatory biomarkers (PlGF, IL-18), and advanced disease modeling. Over 50% of recent work utilizes multimodal approaches combining neuroimaging, molecular biology, and 3D tissue engineering.
Dr. Hinman leads the Hinman Lab at UCLA and collaborates on national consortia including MarkVCID and Diverse VCID. He mentors junior investigators but no formal PhD/Master's advisees are listed. Current NIH funding includes R01NS112799 (shear stress in atherosclerosis), RF1NS114336 (white matter repair), and R56AG069115 (tauopathy mechanisms).
