معرفی
Jan Freark de Boer is an active researcher specializing in bile acid metabolism and cholesterol transport mechanisms, with significant contributions to understanding metabolic diseases using genetically modified mouse models. His work frequently involves CRISPR/Cas9 technology for creating humanized bile acid compositions in experimental models.
His primary research interests include:
- Bile acid composition and its impact on metabolic health
- Cholesterol transport mechanisms and atherosclerosis development
- Interactions between gut microbiome and host metabolism
- Genetic models of metabolic disorders
Dr. de Boer's publication record demonstrates consistent output in high-impact journals covering molecular mechanisms of bile acid signaling, with particular emphasis on CYP2C70 knockout models. His research shows strong interdisciplinary connections between molecular biology, cardiology, and gastroenterology.
Notable scientific activities include frequent invited presentations at major conferences including the European Liver Meeting (EASL) and Dutch Liver Retreat, where he has presented findings on humanized bile acid pools and their metabolic effects.
He has supervised multiple research projects and maintains active collaborations with Prof. Folkert Kuipers and other researchers in the Netherlands. His work contributes to UN Sustainable Development Goals related to good health and well-being through advancing understanding of metabolic diseases.
