معرفی
James Engert is an Associate Professor at McGill University's Faculty of Medicine and Health Sciences, with dual appointments at the McGill University Health Centre (Division of Cardiology) and as a Scientist in the Cardiovascular Health Across the Lifespan Program at the Research Institute of the MUHC. His work bridges cardiovascular genetics, epidemiology, and translational medicine.
Research Interests:
- Genetic etiology of cardiovascular diseases (myocardial infarction, dilated cardiomyopathy, aortic stenosis)
- Gene-environment interactions in disease susceptibility
- Mendelian randomization and genome-wide association studies (GWAS)
- Pharmacogenomics of cardiovascular therapies
- Development of genetic risk scores for prognosis
Methodologies: Engert's team integrates clinical data from MUHC patients with large-scale public datasets, focusing on aortic stenosis across diverse ethnicities. They employ advanced statistical genetics, proteomics, and molecular modeling to uncover novel therapeutic targets.
Publications: His recent work appears in JAMA Cardiology and Circulation, with a focus on lipoprotein(a) metabolism, TLR3-mediated calcification, and MFSD5 inhibition mechanisms in valvular disease. Collaborative projects emphasize cross-disciplinary approaches to cardiovascular pathogenesis.