James E. Hansen

James E. Hansen is an Associate Professor of Therapeutic Radiology at Yale School of Medicine. He serves as Chief of the Gamma Knife Program and Co-Director of the Stereotactic Radiosurgery and Body Radiotherapy Fellowship. His clinical expertise spans Gamma Knife radiosurgery, SBRT, and treatment of CNS, head/neck, lung, and GI/GU cancers.

• Appointments: Yale School of Medicine, Yale Cancer Center, Center for Gastrointestinal Cancers
• Education: MD and MS from UCLA, residency/chief residency at Yale

Research Interests focus on harnessing autoantibodies from autoimmune diseases (e.g., lupus, scleroderma) for cancer therapy. His work explores mechanisms to cross the blood-brain barrier, DNA repair inhibition, and radiation-immunology interactions. Key collaborations include Veronica Chiang, Caroline Johnson, and Jiangbing Zhou.

Publication Trends highlight autoantibody-based tumor targeting, stereotactic radiosurgery advancements, and radiation-immunomodulation. Notable studies include lupus autoantibodies activating tumor immunity (Science Signaling 2025), DNA-guided cancer therapies (ACS Central Science 2024), and blood-brain barrier transport (JCI Insight 2021).

Clinical Trials include Phase IB/II trials on dose-deescalated SBRT for lung cancer. His leadership in radiation safety and co-editorship of clinical guidelines underscores practical impacts.