معرفی
Jagdeep Nanchahal is Professor of Hand, Plastic and Reconstructive Surgery at the University of Oxford, affiliated with Wolfson College. His research group focuses on treating fibrosis and improving tissue regeneration, with major contributions to understanding and targeting fibrotic disorders like Dupuytren’s disease.
- PhD funded by UK Medical Research Council (MRC)
- Chief Investigator for anti-TNF clinical trials in Dupuytren’s disease and frozen shoulder
- Co-applicant on anti-TNF trials for post-hip fracture delirium prevention
- Developing HMGB1 as a regenerative therapy with Wellcome Trust Innovator Award
Research interests include fibrosis mechanisms, translational medicine, and evidence-based surgical protocols. His work spans molecular discovery (TNF, HMGB1, collagen VI) and clinical implementation of novel therapies. Publications highlight therapeutic development for fibrotic diseases and trauma surgery guidelines.
Scientific contributions include:
- Landmark TNF inhibition trials in Dupuytren’s disease
- HMGB1-induced stem cell activation for tissue repair
- Collagen VI-CREBBP/EP300 pathway characterization
- Leadership in NICE Guidance Development Groups
He has secured funding from the Wellcome Trust, Department of Health, and 180 Life Sciences, with recent focus on guideline implementation barriers and healthcare policy optimization.
