Laurence Pearmain

Dr Laurence Pearmain is a NIHR Clinical Lecturer at the Division of Diabetes, Endocrinology & Gastroenerology, University of Manchester. His research focuses on respiratory medicine and fibrotic diseases, with a particular emphasis on pulmonary fibrosis, interstitial lung disease, and post-COVID-19 complications. He holds a PhD in Medical Science from the University of Manchester and is affiliated with the University Hospital of South Manchester NHS Foundation Trust as an Honorary Specialist Registrar (SpR) in Interstitial Lung Disease (ILD) and Respiratory Medicine.

• Doctor of Science (Medical Science), University of Manchester (2021)
• Master of Research (Medical Research), University of Manchester (2016)
• Member of the Royal College of Physicians (MRCP)
• Bachelor of Medicine, University of Leeds (2011)
• Bachelor of Arts (Biomedical Ethics), University of Leeds (2009)

Dr Pearmain’s research spans molecular mechanisms of fibrosis, including mechanotransduction pathways (PAK1 signaling), extracellular matrix dynamics, and monocyte/macrophage roles in lung injury. His work intersects immunology and respiratory pathology, with recent studies on long-COVID immune profiling and metabolomic changes in fibrotic lung disease. He actively supervises PhD students and collaborates internationally on clinical trials for fibrosis therapies.

Key trends in his research output include:

• Development of preclinical fibrosis models (organoids, cell lines)
• Translational studies in interstitial lung disease and acute lung injury
• Clinical trial analysis for anti-fibrotic therapies (e.g., BI 101550, RELIEF trials)

He serves as a reviewer for journals like Breathe and Journal of Breath Research, contributing to open-access scientific literature. His work aligns with UN Sustainable Development Goals for advancing medical science and global health.