معرفی
Hyeon Jun Shin is an Associate Research Scientist in the Department of Pulmonary, Critical Care & Sleep Medicine at Yale School of Medicine. His research focuses on immunology, pulmonary medicine, and molecular pathology, with particular emphasis on mechanisms underlying lung injury, autoimmune diseases, and infectious diseases. He collaborates with experts such as Dr. Brian Clark and Dr. Edward Manning to investigate topics like T helper cell dysfunction, EGFR signaling in lung pathology, and MAVS-mediated immune responses.
Key research interests include understanding how genetic deletions (e.g., 17q12) impact immune function, the role of autophagy in hyperoxic lung injury, and developing therapeutic targets for pulmonary fibrosis and viral infections. His work bridges basic science and clinical applications, aiming to translate molecular findings into novel treatments.
Recent studies highlight contributions to understanding SARS-CoV-2 pathogenesis, the role of chitinase 3-like-1 in aging-related immunity, and the development of anti-inflammatory peptides targeting TLR pathways. Collaborative efforts with pharmaceutical researchers aim to create novel inhibitors for endosomal TLRs and EGFR pathways.
Publications span prestigious journals like EBioMedicine and *AJRCCM Conference Abstracts, reflecting a strong focus on translational research. His work frequently addresses cytokine regulation, mitochondrial dysfunction, and immune checkpoint modulation in respiratory diseases.
