Hung-Ying Kao

Hung-Ying Kao is a Professor in the Department of Biochemistry at the School of Medicine, Case Western Reserve University, where she also serves as Director of Graduate Programs. She is a member of the Molecular Oncology Program at the Case Comprehensive Cancer Center, reflecting her deep engagement in cancer research.

Her research focuses on the molecular mechanisms of breast cancer, particularly ERα-positive and endocrine-resistant subtypes. Using biochemical and molecular approaches, her lab investigates how transcription and signaling networks control cell fate. Key areas include the oncogenic role of the PML1 spliced isoform and the discovery of small molecules that target the ERα domain interface to overcome drug resistance.

Recent publications (2024–2025) highlight ongoing work on PML1-mediated feedforward loops, ERα structural dynamics, and drug repurposing (e.g., mitoxantrone). These studies span cancer biology, structural biology, and pharmacology, demonstrating a multidisciplinary approach to understanding and treating breast cancer.

• Honors and Awards: None listed in the provided text.

Dr. Kao advises graduate students as Director of Graduate Programs and leads a research team exploring novel anticancer targets. Her lab investigates PML isoforms, ERα signaling, and redox regulation in cancer. Collaborations with Dr. Sichun Yang in Nutrition underscore her integrative research strategy. While specific grants are not mentioned, her ongoing projects suggest active funding in molecular oncology and translational cancer research.