معرفی
Hongying (Hoy) Shen is an Assistant Professor in Cellular & Molecular Physiology at Yale School of Medicine and Systems Biology Institute at Yale West Campus since January 2020. Her research focuses on cellular metabolism, using interdisciplinary approaches including biochemistry, genetics, and metabolomics to study enzymes and transporters critical to human health and disease. She is particularly known for her work on 'deorphanizing' uncharacterized proteins in the human genome, especially those involved in mitochondrial function and metabolism.
Dr. Shen received her B.S. in Chemistry from Nanjing University (2006) and her Ph.D. in Molecular Biophysics and Biochemistry from Yale University (2013). Her postdoctoral training at Massachusetts General Hospital/Harvard Medical School with Dr. Vamsi Mootha established her expertise in CRISPR screens and metabolomics. She has been recognized with prestigious awards including the Rita Allen Foundation Scholar (2023) and the Klingenstein-Simons Fellowship (2021).
Her lab investigates mitochondrial transporters, metabolic pathways, and their roles in diseases like cancer and cystic disorders. Recent work includes identifying NAT10 as a master regulator of brain metastasis and elucidating the role of SLC25A39 in mitochondrial glutathione transport. Collaborations span Yale’s Diabetes Research Center, Interdepartmental Neuroscience Program, and the Wu Tsai Institute.
Notable achievements include over 30 peer-reviewed publications, including high-impact articles in Cell, Nature Communications, and Molecular Cell. Her research bridges basic science and translational medicine, aiming to uncover new diagnostic and therapeutic targets.