معرفی
Lei Shen is an Associate Research Scientist in the Department of Internal Medicine at Yale School of Medicine. His research focuses on immunometabolism, immune cell regulation, and their roles in metabolic diseases such as diabetes and cancer. Key areas include investigating cytokine pathways (IL-22, PD-1), mitochondrial homeostasis, and transcriptional regulation in immune cells. He employs advanced techniques like single-cell transcriptomics and molecular biology to study adipose tissue, innate lymphoid cells (ILC2/3), and tumor microenvironments.
Publications highlight contributions to understanding Sirtuin 6's role in gut immunity, LKB1's dual impact on insulin resistance and antitumor immunity, and the interplay between liver immune cells and gluconeogenesis. Collaborations include work with Bing Su, Lichong Yan, and teams at Yale's Department of Internal Medicine and other institutions.
No formal awards or grants are listed in the provided materials. Advising roles or student mentorship information is not explicitly stated. Research activities are centered on translational immunology with implications for metabolic and oncologic therapies.
