معرفی
Xia Lei is an Assistant Professor in the Department of Biochemistry and Molecular Biology at Oklahoma State University since 2019. He holds an MD from Zhengzhou University (2003) and a PhD in Biochemistry & Molecular Biology from the Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (2010). His research focuses on immunometabolic regulation, particularly the role of C1q/TNF-related proteins (CTRP family) in obesity, diabetes, and metabolic diseases. Dr. Lei explores how CTRP6 links adipose inflammation to systemic glucose metabolism using mouse models and molecular techniques.
Key research areas include CTRP protein function, macrophage inflammatory pathways, and therapeutic target discovery. His lab employs genetic mouse models, RNA-seq, flow cytometry, and metabolomics. Notable findings include CTRP6's dual role in modulating insulin sensitivity and pro-inflammatory responses in adipose tissue. Recent work investigates CTRP6 variants in cancer associations and dietary amino acid impacts on neonatal glucose metabolism.
Dr. Lei has secured grants including NIH-funded studies on immunometabolic regulation and participation in the Oklahoma Center for Respiratory and Infectious Diseases (CoBRE). He teaches courses on disease and metabolism, molecular metabolism, and supervises undergraduate/graduate research. His work bridges basic science and translational medicine, aiming to develop novel treatments for metabolic disorders.
