معرفی
Dr. Heidi L. Schubert is a researcher at the University of Utah's Department of Biochemistry, with over 25 years of experience in structural biology. She specializes in X-Ray Crystallography and Cryogenic Electron Microscopy (Cryo-EM), focusing on HIV protein interactions, chromatin remodeling complexes, and mitochondrial signaling pathways. As manager of the Bacterial Expression Core Facility of the CHEETAH Center (P50 GM082545), she supports researchers in recombinant protein expression and purification projects aimed at elucidating molecular mechanisms of HIV infection.
Her research interests include:
- Cryogenic Electron Microscopy and Three-Dimensional Reconstruction
- Nucleosome Remodeling and Chromatin Dynamics
- Structural Basis of HIV Protein Interactions
- Mitochondrial Stress Responses
Dr. Schubert has contributed to multiple high-impact publications, including the first Cryo-EM structure of spastin (2020) and collaborative work on SWI/SNF chromatin remodeler architecture (2013). She plays a primary role in cryo-EM projects within the Hill Lab, guiding all aspects from sample preparation to structure refinement.
Recent publications demonstrate expertise in:
- Structural analysis of HIV restriction factors (BST2/tetherin)
- Crystallographic studies of metabolic enzymes (malate synthase, isopentenyl phosphate kinase) Mechanistic studies of mitochondrial fission complexes
- Investigations of cofactor biosynthesis pathways (vitamin B12)
