Haseeb A. Siddiqi

Dr. Haseeb A. Siddiqi is an Associate Professor in the Department of Cell Biology at the State University of New York Downstate Medical Center. His roles include:

• Clinical Director, Clinical Parasitology and Diagnostic Immunology Laboratories, Kings County Hospital Center
• Block Director, MS2 Gastrointestinal Diseases
• Discipline Director, MS2 Microbiology & Immunology
• Chairman, Institutional Biosafety Committee
• Member, Animal Care and Use Committee

Dr. Siddiqi's research centers on schistosomiasis, a chronic parasitic disease affecting 200-300 million people globally. He investigates host-parasite interactions, pathogenesis mechanisms, and schistosome reproductive biology, with emphasis on chemoattraction between male and female worms. His work explores how tumor necrosis factor (TNFα) regulates egg production and granuloma formation, and how blood group antigens (particularly blood group A) influence disease severity through GalNAc-containing receptors like GP50.

His publication record spanning 1988-2009 reveals consistent focus on schistosome molecular mechanisms. Early work established male-released chemoattractants and female receptors, while later studies examined TNFα effects on fecundity and blood group-related pathogenesis. Publications integrate parasitology, immunology, and glycobiology to address schistosomiasis pathology and potential interventions targeting reproductive biology.

Dr. Siddiqi directs clinical diagnostic laboratories at Kings County Hospital Center, overseeing parasitology and immunology testing. His laboratory employs in vitro bioassays to study schistosome chemoattraction, nutrient uptake, and cytokine impacts, with findings demonstrating SBA/GalNAc-mediated chemoreception and TNFα-induced suppression of egg production.