معرفی
H. Robert Frost is an Associate Professor of Biomedical Data Science and Molecular and Systems Biology at the Geisel School of Medicine, Dartmouth College. He serves as Associate Director of the Quantitative Biomedical Sciences Graduate Program, contributing to academic leadership and graduate education.
- Education: PhD from Dartmouth College (2014), MS (1995) and BS (1993) from Stanford University
Dr. Frost's research focuses on developing bioinformatics and biostatistics methods for high-dimensional genomic data. Key areas include dimensionality reduction (e.g., PCA), hypothesis aggregation (e.g., gene set testing), penalized estimation (e.g., LASSO regression), cell signaling analysis, tissue-specific gene activity, tumor immunology, and computational approaches to cancer prognosis prediction. Recent work emphasizes spatial transcriptomics data analysis, single-cell RNA sequencing methods, and chromatin accessibility integration.
His research is supported by NIH grants R35GM146586 and R21CA253408, with publications spanning cancer transcriptomics, pathogen immunology, and spatial data algorithms. The 2025 publications highlight methodological innovations in gene set optimization and spatial transcriptomics analysis, while 2024 work includes pathogen-host interactions and multi-omics tool development.
- Key Collaborations: Involvement in tumor immunology, germinal center dynamics, and pathogen-specific immunity research
