معرفی
Dr. Greg Ngo is a Research Fellow at Cardiff University's School of Medicine, focusing on genome stability and DNA repair mechanisms. His research explores R-loop formation at DNA double-strand breaks (DSBs) and its impact on neurodevelopmental disorders like autism spectrum disorder (ASD) and ADHD. Funded by a Wellcome Trust Career Development Award, his lab investigates the molecular links between R-loops, genome instability, and disease pathogenesis. Ngo’s multidisciplinary approach combines genetics, biochemistry, and neuroscience techniques, including CRISPR, next-generation sequencing, and induced pluripotent stem cell technologies. He has contributed significantly to understanding DNA repair pathways in yeast, archaea, and human cells. Key achievements include discovering R-loop roles in DSB repair and demonstrating PARP inhibitors' efficacy in targeting telomere-driven cancer progression.
Education and career highlights include a D.Phil. from the University of Oxford under Prof. Ian Hickson, postdoctoral work at Newcastle University with Prof. David Lydall, and research collaborations at Cardiff University with Prof. Duncan Baird. His lab currently includes Dr. Siamak Kamranvar and PhD student Angelos Damo. Ngo’s work bridges fundamental research with translational applications in cancer therapy and neurodevelopmental disorder mechanisms.
Research interests span DNA repair mechanisms, R-loop biology, telomere dysfunction, and neurodevelopmental disorders. Recent studies highlight UPF1’s role in R-loop-mediated DNA repair and its implications for intellectual disability and autism. His articles analyze genetic interactions, DNA damage responses, and homologous recombination pathways, with a focus on translating mechanistic insights into clinical contexts.
- Awards: Wellcome Trust Career Development Award (2023)
- Labs/Teams: R-loops & Genome Stability Lab at Cardiff University
- Future Work: Investigating R-loop dynamics in neurodevelopmental disorders using patient-derived iPSCs and advanced genomic tools.
