معرفی
Sherif El-Khamisy is Professor of Molecular Medicine in the School of Biosciences at the University of Sheffield, where he also serves as Deputy Director of the Healthy Lifespan Institute. He leads an active research group investigating DNA repair mechanisms and their roles in neurodegeneration and cancer. His lab is affiliated with the Neuroscience Institute and collaborates widely across clinical and translational research domains.
Education and Career
El-Khamisy earned his PhD in Biochemistry from the University of Sussex (2002–2005). He held postdoctoral positions at St Jude Children’s Research Hospital (USA) and the University of Sussex, before joining the University of Sheffield in 2008. He has held continuous academic leadership roles, including Chair of Molecular Medicine and Wellcome Trust Investigator.
Research Interests
His research focuses on DNA repair, particularly the repair of topoisomerase-mediated and oxidative DNA damage, and its implications in neurodegenerative diseases (e.g., ALS, Huntington’s, ataxias) and cancer. His lab explores mitochondrial DNA repair, R-loops, transcription-coupled repair, and genomic instability in stem cells and aging. He integrates genetics, biochemistry, and clinical insights to uncover novel pathways and therapeutic strategies.
Publication Trends
His recent work (2022–2025) emphasizes oxidative DNA damage in regulatory regions, glucose-induced genotoxicity, cancer-specific glycosylation, and mechanisms of chemotherapy resistance. There is a strong focus on translational applications, including nanomedicine, biomarker discovery, and personalized therapy, often using zebrafish and human cell models.
Scientific Awards and Honors
- Wellcome Trust Investigator Award
- Lister Research Fellow
- Fellow of the Royal Society of Chemistry
- Fellow of the Royal Society of Biology
- Fellow of the Lister Institute of Preventative Medicine
- Shoman Award for Medical Sciences
- Sir Richard Stapley Award, UK
- Lorne Duncan Award, UK
Advising and Grants
El-Khamisy actively mentors PhD and postdoctoral researchers, with former students establishing independent careers. His group has received funding from the Wellcome Trust, Lister Institute, and collaborations with AstraZeneca and CRUK. He has led drug discovery initiatives and developed novel genomic technologies with clinical applications.
Labs and Teams
He leads the El-Khamisy Lab, which investigates DNA repair in disease models. The lab has developed zebrafish models, conducted drug screens with Artios Pharma, and collaborated with industry on diagnostic tools. The team includes postdocs, PhD students, and clinical fellows working on neurodegeneration, cancer, and stem cell genomics.
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