معرفی
J. Ross Chapman is a Professor of Genome Maintenance Biology at the University of Oxford, holding positions at the MRC Molecular Haematology Unit (part of the Radcliffe Department of Medicine) and the Wellcome Centre for Human Genetics. He is a Cancer Research UK (CRUK) Career Development Fellow, Lister Institute Research Fellow, and EMBO Young Investigator Programme member. His research focuses on DNA repair mechanisms, particularly the balance between accurate and mutagenic repair pathways in cancer and immune systems. Key affiliations include the Francis Crick Institute and previous roles at the University of Sussex and Gurdon Institute.
Education and Career Path: Started as a Research Assistant at the MRC Genome Damage and Stability Centre (2002), earned his PhD in Steve Jackson’s lab (2006), and held postdoctoral roles at Simon Boulton’s lab (2010). Established his independent group at Oxford in 2013, becoming an Associate Professor in 2017 and moving to the MRC Unit in 2020.
Research Interests: Investigates genetic recombination mechanisms, DNA double-strand break (DSB) repair pathways, and their roles in immune system development and cancer. Recent work explores how faulty repair mechanisms drive cancer and immune disorders, targeting vulnerabilities for therapies like PARP inhibitors.
Publications: Recent studies include discoveries on Shieldin/CST complex roles in DNA repair, BLM-BRCA1 interactions, and chronic inflammation in leukemia. His work bridges basic biology with clinical applications, such as drug resistance mechanisms in BRCA-deficient cancers.
Awards: CRUK CDF, Lister Fellowship, EMBO Young Investigator Programme membership, and recognition for contributions to DNA repair research.
Lab Team: Includes postdoctoral researchers (e.g., Ashleigh King, My Khanh Pham), DPhil students, and technical staff. Collaborates on projects like PARP inhibitor efficacy and immune system DNA repair dynamics.
