معرفی
Gonçalo Castelo-Branco is a Professor in the Department of Medical Biochemistry and Biophysics at Karolinska Institutet's Faculty of Medicine, where he leads an active research group focused on oligodendrocyte biology and epigenomics. His laboratory investigates the molecular mechanisms defining transcriptomic and epigenomic states of oligodendrocyte lineage cells in the central nervous system, particularly in the context of neuroinflammatory and demyelinating diseases like multiple sclerosis.
His research employs state-of-the-art technologies including single-cell and spatial transcriptomics and epigenomics, CRISPR-based screens, and advanced computational approaches applied to rodent models of disease and human patient material. His team has made significant contributions to understanding oligodendrocyte heterogeneity, epigenetic regulation of myelination, and disease-specific oligodendrocyte states in multiple sclerosis.
The publication analysis reveals a strong focus on developing and applying cutting-edge spatial and single-cell omics technologies to study neurodevelopment and neuroinflammatory diseases. His recent work (2022-2024) prominently features spatial epigenomics and multi-omic approaches that simultaneously profile chromatin accessibility, histone modifications, transcriptomes, and proteomes within the same tissue sections.
Castelo-Branco is actively involved in several collaborative networks including KNIMS (The Karolinska Neuroimmunology & Multiple Sclerosis Network) and maintains multiple web resources for his datasets, most notably the OligoInternode interface which allows researchers to explore gene expression patterns in oligodendrocyte lineage cells.
His research program receives substantial funding supporting the development of epigenetic-based therapies to induce regeneration/remyelination and prevent neuroinflammation in demyelinating diseases. The laboratory maintains strong international collaborations with institutions including Stockholm University, Yale University, and multiple European research centers.
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