Giorgio Mangino

Giorgio Mangino is an Associate Professor at the Department of Medical-Surgical Sciences and Biotechnologies, Faculty of Pharmacy and Medicine, Sapienza University of Rome. His research focuses on HPV tumor microenvironment, exosomes and microvesicles, Signal Transduction, microRNA, and inflammatory diseases. With a career spanning multiple decades, he has established himself as a leading researcher in viral oncology and immunology, particularly in understanding how HPV oncoproteins modulate cellular signaling and immune responses.

Dr. Mangino earned his Laurea in Biological Sciences with highest honors (110/110 cum laude) from Sapienza University of Rome in 1995, followed by a PhD in Immunological Sciences in 2006. His educational journey included specialized training in flow cytometry, biostatistics, and English language proficiency (Trinity College Grade 7 certification). He has held various research positions at University of Rome Tre and Sapienza University before securing his current position as Associate Professor.

His research trajectory evolved from early studies on interferon signaling in erythroleukemic cells, through investigations of HIV-1 Nef protein's effects on macrophage signaling, to his current focus on HPV-induced carcinogenesis. Dr. Mangino has made significant contributions to understanding how viral proteins manipulate host cell signaling pathways, particularly regarding Nef's role in inducing proinflammatory states and HPV oncoproteins' effects on microRNA expression and tumor microenvironment modulation.

Dr. Mangino's recent publications reveal a strong emphasis on translational research, particularly in developing extracellular vesicle-based biomarkers for skin cancer diagnosis and understanding immune profiles in autoimmune disorders. His work bridges fundamental virology with clinical applications, demonstrating consistent evolution from basic mechanisms to potential diagnostic and therapeutic approaches.

Scientific Awards:

• Seymour and Vivian Milstein Travel Award (2005, 2006, 2007, 2011)
• Eurovirology Travel Grant (2007)
• Best Poster Award of Società Italiana di Virologia (2008)

As a cytometrist, Dr. Mangino collaborates extensively across multiple research projects requiring advanced cellular analysis techniques. He has served as thesis advisor for numerous Master's students and teaches courses in immunology, virology, and laboratory medicine. His current research projects focus on extracellular vesicle-based diagnostics for skin lesions, biomarker discovery in actinic keratosis progression, and immune profiling of patients receiving cancer immunotherapies. Dr. Mangino directs the Flow Cytometry Laboratory at Sapienza University, supporting a wide range of research initiatives within the Department of Medical-Surgical Sciences and Biotechnologies.