معرفی
Gary Gibson is a tenured Professor of Neuroscience at Weill Cornell Medicine and serves as Lab Director at the Burke Neurological Institute. He leads the Laboratory for Mitochondrial Biology and Metabolic Dysfunction in Neurodegeneration, focusing on age-related neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease.
- Educational background:
- Ph.D. in Physiology (Biochemistry/Neuroscience), Cornell University
- B.S. in Zoology and Chemistry, University of Wyoming
His research investigates how mitochondrial dysfunction, reduced glucose metabolism, and oxidative stress contribute to neurodegeneration. He explores therapeutic interventions targeting these mechanisms, including benfotiamine for improving thiamine levels and modulating post-translational modifications of mitochondrial enzymes like the α-ketoglutarate dehydrogenase complex (KGDHC). These studies integrate human autopsy samples, genetically modified cells, and transgenic mouse models to test hypotheses about calcium dysregulation, free radical damage, and inflammatory cascades.
Recent publications highlight his work on mitochondrial enzyme plasticity, nutritional metabolism in dementia, and benfotiamine's neuroprotective effects in clinical trials. He has secured continuous NIH funding (Grant R01AG043679) and holds three U.S. patents. Dr. Gibson serves on editorial boards for Neurochemical Research, Neurochemical International, and Journal of Neurochemistry, and has mentored undergraduate students and postdoctoral researchers.
