معرفی
Ryan Mailloux is an Associate Professor and Director of the School of Human Nutrition at McGill University, within the Faculty of Agricultural and Environmental Sciences. He holds a PhD in Biomolecular Sciences from Laurentian University (2008) and completed postdoctoral training at the University of Ottawa and Carleton University/Health Canada. Prior to joining McGill in 2019, he was a tenure-track faculty member at Memorial University of Newfoundland.
His research focuses on mitochondrial redox biology, particularly mitochondrial hydrogen peroxide (H₂O₂) generation in liver cells and its role in health and disease. Key interests include understanding how H₂O₂ regulates cellular communication, contributes to metabolic dysfunction-associated fatty liver disease (MAFLD), and influences cancer progression through redox signaling pathways. His lab has identified novel mechanisms like S-glutathionylation and S-nitrosylation that modulate H₂O₂ production, with applications in therapeutic development.
Mailloux has published over 94 articles, emphasizing mitochondrial bioenergetics, oxidative stress, and redox homeodynamics. Current work explores H₂O₂ regulation via enzymes like α-ketoglutarate dehydrogenase (KGDH) and dihydroorotate dehydrogenase (DHO-DH), with implications for treating MAFLD and hepatocellular carcinoma (HCC). Collaborative projects target H₂O₂-generating sites for drug development.
Teaching responsibilities include NUTR 307 (Metabolism and Human Nutrition), NUTR 507 (Advanced Nutritional Biochemistry), and NUTR 606 (Human Nutrition Research Methods). He actively recruits postdoctoral fellows with expertise in nutrient metabolism and redox biology. His research is supported by grants exploring mitochondrial dysfunction in metabolic diseases and cancer.
Mailloux's work highlights the dual role of mitochondrial H₂O₂ as both a signaling molecule (oxidative eustress) and a driver of pathology (oxidative distress). Recent findings reveal cancer cells exploit deregulated H₂O₂ pathways to promote proliferation, while his lab’s discoveries on glutaredoxin-2 (Glrx2) gene deletion offer insights into NAFLD prevention.
