Gareth Howell

Gareth Howell is a Professor at the Graduate School of Biomedical Science and Engineering within The Jackson Laboratory in Orono, Maine. His research focuses on neurodegenerative diseases, particularly Alzheimer's disease and glaucoma, with an emphasis on microglial biology, genetic risk factors, and disease mechanisms. He leads studies on mouse models to elucidate pathways linking neurodegeneration, vascular dysfunction, and aging.

Research Interests: Dr. Howell's work integrates molecular biology, genetics, and systems biology to study Alzheimer's, glaucoma, and their comorbidities. Key areas include microglia-synaptic interactions, APOE genotype effects, and metabolic signatures in disease progression. His lab explores translational approaches to identify therapeutic targets using multi-omics profiling and genetic engineering.

Publications: Recent work highlights Alzheimer's-bone health intersections, microglia depletion in glaucoma, and validation of genetic risk factors in vivo. His studies often combine mouse models with advanced imaging and metabolomic techniques to uncover disease mechanisms.

Collaborations: He contributes to the Jackson Laboratory's Center for Alzheimer's and Dementia Research, advancing preclinical models for drug discovery and precision medicine. His interdisciplinary approach bridges neuroscience, immunology, and biomedical engineering.