Alison M Goate

Alison M Goate is a **Professor & Chair of the Department of Genetics & Genomic Sciences** at the **Icahn School of Medicine at Mount Sinai**, with additional appointments in **Neuroscience** and **Neurology**. She leads the **Ronald M. Loeb Center for Alzheimer’s Disease** and the **Alzheimer’s Disease Research Center**. Her work focuses on **Alzheimer’s disease (AD)** and **addiction (alcohol use disorder)**, integrating genetic, genomic, and stem cell approaches to identify therapeutic targets. Notable roles include **Jean C. & James W. Crystal Professor**, **Director of the Ronald Loeb Center**, and **Elected Member of the National Academy of Medicine**.

**Education**: BSc (Hons) from University of Bristol; DPhil (Oxford University); Postdoctoral research at Eleanor Roosevelt Institute, University College London, and Imperial College London.

**Research Interests**: Molecular mechanisms of AD and FTD, genetic risk factors (e.g., SPI1, APOE, MS4A), microglial biology, iPSC-derived models, and shared genetic links between AD and alcoholism. Projects include **FASe Project** (family-based AD genetics), **COGA Study** (genetics of AUD), and **DIAN Genetics Core** (dominant AD mutations).

**Awards**: 2023 Piepenbrock-DZNE Prize, 2022 Rainwater Prize, Potamkin Prize (1993), and **Lifetime Achievement Awards** from Alzheimer’s Association (2015). Over 740 publications in top journals like *Alzheimer’s Research & Therapy*, *Cell Reports*, and *Acta Neuropathologica*.

**Grants/Leadership**: NIH-funded projects on AD genetics, AUD, and stem cell modeling. Lab members include **Edoardo Marcora**, **Alan Renton**, and 15+ trainees.

**Lab Focus**: iPSC-derived microglia/macrophages, organoid models of tauopathies, and drug development targeting PU.1/SPI1 pathways. Collaborations include **Dr. Anne Schaefer** (mouse models), **Slesinger Lab** (GIRK2 in AUD), and **BrainXell** (neural cell production).