معرفی
Prof. G.V. Shivashankar is a Full Professor of Mechano-Genomics at ETH Zurich and holds a joint appointment at the Paul Scherrer Institute (PSI), Switzerland. He previously served as Deputy Director of the Mechanobiology Institute (MBI) at the National University of Singapore (NUS), where he also held the IFOM-NUS Chair Professorship. His research focuses on nuclear mechanics, genome regulation, and cancer diagnostics, integrating optical imaging, machine learning, and functional genomics.
Educated at The Rockefeller University (PhD, 1994–1999) and with postdoctoral training at NEC Research Institute, he has led groundbreaking studies on nuclear mechanogenomics and mechano-driven cell fate transitions. Awards include the Birla Science Prize (2006), Swarnajayanthi Fellowship (2007), and EMBO membership (2019).
His work bridges disciplines, exploring how mechanical forces influence nuclear architecture and gene regulation. He leads the Laboratory of Multiscale Bioimaging at PSI, collaborating with IFOM in Milan. Current projects include developing nuclear biomechanical markers for early cancer diagnosis and AI-driven analysis of chromatin dynamics.
Grants include support from the Mechanobiology Institute, Ministry of Education (Singapore), and the IFOM-MBI Joint Lab. Notable achievements include detecting chemoresistant cancer cells via chromatin biomarkers and reprogramming fibroblasts for tissue regeneration. His lab actively mentors students and collaborates globally on mechanobiology applications in health and disease.
