Francesco Tamagnini

Francesco Tamagnini is a Lecturer in Pharmacology at the University of Reading, affiliated with the School of Chemistry, Food & Pharmacy. His research focuses on neurophysiological markers of dementia, particularly Alzheimer’s disease, integrating preclinical studies with clinical translation to develop early diagnostic methods. He employs advanced techniques such as chemical imaging, electrophysiology, and computational modeling to study synaptic dysfunction and neural network dynamics. Beyond academia, he engages in artistic and public outreach initiatives to communicate scientific findings.

His research interests span tauopathy, lipid biomarkers, and neurodegenerative mechanisms. He has contributed to studies on synaptic plasticity, pain pathway modulation, and the role of omega-3 fatty acids in vascular health. Tamagnini’s work often involves mouse models to investigate disease progression and potential therapeutic interventions.

Key areas of exploration include the interplay between tau protein pathology and HCN channel dysfunction, the development of novel diagnostic tools like the textured Novel Object Recognition Test (tNORT), and the application of deep learning to model neuronal dynamics. His findings have implications for understanding disease mechanisms and advancing early diagnosis and treatment strategies.